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In transgender men, or trans masculine people FTM , the most common medication used for transition is testosterone. Administration of testosterone via transdermal, intramuscular, subcutaneous, or oral routes lowers serum estradiol levels, raises serum testosterone levels, and results in the development of typical male secondary sex characteristics. Irreversible changes include: deepening of the voice, increase in facial and body hair growth, clitoral enlargement clitoromegaly , and thickened facial bone structure. Some trans men also describe changes in emotions e.

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Many transgender men and women seek hormone therapy as part of the transition process. Exogenous testosterone is used in transgender men to induce virilization and suppress feminizing characteristics. In transgender women, exogenous estrogen is used to help feminize patients, and anti-androgens are used as adjuncts to help suppress masculinizing features. Guidelines exist to help providers choose appropriate candidates for hormone therapy, and act as a framework for choosing treatment regimens and managing surveillance in these patients.
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Persons whose experienced or expressed gender differs from their sex assigned at birth may identify as transgender. Transgender and gender-diverse persons may have gender dysphoria i. Gender identity is distinct from sexual orientation, sex development, and external gender expression. Each construct is culturally variable and exists along continuums rather than as dichotomous entities.
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Leuprorelin , also known as leuprolide or by the brand name Lupron, is a manufactured version of a hormone used to treat prostate cancer , breast cancer , endometriosis , uterine fibroids , and early puberty. Common side effects include hot flashes , unstable mood, trouble sleeping , headaches , and pain at the site of injection. Leuprorelin was patented in and approved for medical use in the United States in
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